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The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation
The fidelity of chromosome segregation depends on the spindle assembly checkpoint (SAC). In the presence of unattached kinetochores, anaphase is delayed when three SAC components (Mad2, Mad3/BubR1, and Bub3) inhibit Cdc20, the activating subunit of the Anaphase-Promoting Complex (APC/C). We analyzed...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462283/ https://ncbi.nlm.nih.gov/pubmed/22940250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.07.031 |
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