Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

The prevalent DNA modification in higher organisms is the methylation of cytosine to 5-methylcytosine (5mC), which is partially converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) family of dioxygenases. Despite their importance in epigenetic regulation, it is unclear h...

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Bibliographische Detailangaben
Hauptverfasser: He, Yu-Fei, Li, Bin-Zhong, Li, Zheng, Liu, Peng, Wang, Yang, Tang, Qingyu, Ding, Jianping, Jia, Yingying, Chen, Zhangcheng, Li, Lin, Sun, Yan, Li, Xiuxue, Dai, Qing, Song, Chun-Xiao, Zhang, Kangling, He, Chuan, Xu, Guo-Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462231/
https://ncbi.nlm.nih.gov/pubmed/21817016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210944
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