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The genesis of Zelboraf: Targeting mutant B-Raf in melanoma
The protein kinase B-Raf is a critical component of the Ras/MAPK signaling pathway. An oncogenic B-Raf mutation that constitutively activates the kinase was identified in z50% of melanoma patients and in other cancers. A structure-guided drug discovery approach enabled the development of Zelboraf, a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461519/ https://ncbi.nlm.nih.gov/pubmed/23027900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205167 |
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