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Targeting Mutant (V600E) B-Raf in Melanoma Interrupts Immunoediting of Leukocyte Functions and Melanoma Extravasation

Polymorphonuclear neutrophils (PMN) facilitate melanoma cell extravasation under dynamic flow conditions by the binding of intercellular adhesion molecule-1 (ICAM-1) on melanoma cells to β(2) integrins on PMNs, which is mediated by endogenously produced chemokine interleukin 8 (IL-8) from the tumor...

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Detalhes bibliográficos
Main Authors: Liang, Shile, Sharma, Arati, Peng, Hsin-Hsin, Robertson, Gavin, Dong, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724629/
https://ncbi.nlm.nih.gov/pubmed/17575149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4233
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