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Targeting Mutant (V600E) B-Raf in Melanoma Interrupts Immunoediting of Leukocyte Functions and Melanoma Extravasation
Polymorphonuclear neutrophils (PMN) facilitate melanoma cell extravasation under dynamic flow conditions by the binding of intercellular adhesion molecule-1 (ICAM-1) on melanoma cells to β(2) integrins on PMNs, which is mediated by endogenously produced chemokine interleukin 8 (IL-8) from the tumor...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2724629/ https://ncbi.nlm.nih.gov/pubmed/17575149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4233 |
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