Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma

Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf, which leads to constitutive activation and dysregulation of MAP kinase signaling. In order to elucidate molecular determinants responsible for B-Raf control of cancer phenotypes, we present a method for phosphoprotein...

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Hauptverfasser: Old, William M., Shabb, John B., Houel, Stephane, Wang, Hong, Couts, Kasey L., Yen, Chia-yu, Litman, Elizabeth S., Croy, Carrie H., Meyer-Arendt, Karen, Miranda, Jose G., Brown, Robert A., Witze, Eric S., Schweppe, Rebecca E., Resing, Katheryn A., Ahn, Natalie G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735263/
https://ncbi.nlm.nih.gov/pubmed/19362540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.03.007
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