Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

Human melanomas show oncogenic B-Raf mutations which activate the B-Raf/MKK/ERK cascade. We screened microarrays to identify cellular targets of this pathway, and found that genes upregulated by B-Raf/MKK/ERK showed highest association with cell cycle regulators, whereas genes downregulated were mos...

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Hlavní autoři: Argast, Gretchen M., Croy, Carrie H., Couts, Kasey L., Zhang, Zhiyong, Litman, Elizabeth, Chan, Daniel C., Ahn, Natalie G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3238492/
https://ncbi.nlm.nih.gov/pubmed/19483722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.133
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