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Fluorescent reporters of thrombin, heparin cofactor II, and heparin binding in a ternary complex
Thrombin inactivation by heparin cofactor II (HCII) is accelerated by ternary complex formation with heparin. The novel active-site-labeled thrombins, [4′F]FPR-T and [6F]FFR-T, and the exosite I probe, Hir-(54–65)( [Formula: see text]), characterized thrombin exosite I and II interactions with HCII...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461310/ https://ncbi.nlm.nih.gov/pubmed/22206940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.11.021 |
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