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Sucrose Octasulfate Selectively Accelerates Thrombin Inactivation by Heparin Cofactor II
Inactivation of thrombin (T) by the serpins heparin cofactor II (HCII) and antithrombin (AT) is accelerated by a heparin template between the serpin and thrombin exosite II. Unlike AT, HCII also uses an allosteric interaction of its NH(2)-terminal segment with exosite I. Sucrose octasulfate (SOS) ac...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832979/ https://ncbi.nlm.nih.gov/pubmed/20053992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005967 |
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