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Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson’s disease

Mitochondrial oxidant stress is widely viewed as critical to pathogenesis in Parkinson’s disease. But the origins of this stress are poorly defined. One possibility is that it arises from the metabolic demands associated with regenerative activity. To test this hypothesis, neurons in the dorsal moto...

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Detalhes bibliográficos
Main Authors: Goldberg, Joshua A., Guzman, Jaime N., Estep, Chad M., Ilijic, Ema, Kondapalli, Jyothisri, Sanchez-Padilla, Javier, Surmeier, D. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461271/
https://ncbi.nlm.nih.gov/pubmed/22941107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3209
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