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Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

The ability of the Cav1 channel inhibitor isradipine to slow the loss of substantia nigra pars compacta (SNc) dopaminergic (DA) neurons and the progression of Parkinson’s disease (PD) is being tested in a phase 3 human clinical trial. But it is unclear whether and how chronic isradipine treatment wi...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Guzman, Jaime N., Ilijic, Ema, Yang, Ben, Sanchez-Padilla, Javier, Wokosin, David, Galtieri, Dan, Kondapalli, Jyothisri, Schumacker, Paul T., Surmeier, D. James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983329/
https://ncbi.nlm.nih.gov/pubmed/29708514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95898
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