Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Parkinson's disease (PD) is a pervasive, aging-related neurodegenerative disease whose cardinal motor symptoms reflect the loss of a small group of neurons – dopaminergic neurons in the substantia nigra pars compacta (SNc)(1). Mitochondrial oxidant stress is widely viewed as responsible for thi...

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Published in:Nature
Main Authors: Guzman, Jaime N., Sanchez-Padilla, Javier, Wokosin, David, Kondapalli, Jyothisri, Ilijic, Ema, Schumacker, Paul T., Surmeier, D. James
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465557/
https://ncbi.nlm.nih.gov/pubmed/21068725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09536
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