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The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease in developed countries. The core motor symptoms are attributable to the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Why these neurons succumb in PD is not clear. One potential clue...

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Detalhes bibliográficos
Main Authors: Surmeier, D. James, Guzman, Jaime N., Sanchez-Padilla, Javier, Schumacker, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244353/
https://ncbi.nlm.nih.gov/pubmed/21884755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2011.08.045
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