Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Intracellular mechanism(s) that contribute to promiscuous signaling via oncogenic KIT in systemic mastocytosis and acute myelogenous leukemia are poorly understood. We show that SHP2 phosphatase is essential for oncogenic KIT-induced growth and survival in vitro and myeloproliferative disease (MPD)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mali, Raghuveer Singh, Ma, Peilin, Zeng, Li-Fan, Martin, Holly, Ramdas, Baskar, He, Yantao, Sims, Emily, Nabinger, Sarah, Ghosh, Joydeep, Sharma, Namit, Munugalavadla, Veerendra, Chatterjee, Anindya, Li, Shuo, Sandusky, George, Craig, Andrew W., Bunting, Kevin D., Feng, Gen-Sheng, Chan, Rebecca J., Zhang, Zhong-Yin, Kapur, Reuben
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2012
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460688/
https://ncbi.nlm.nih.gov/pubmed/22806893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-08-375873
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