Structural basis for activation of the complement system by component C4 cleavage

An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical pathways, two of the three well-established activation pathways of the complement system. This recognition causes activation of the MASP-2 or the C...

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Main Authors: Kidmose, Rune T., Laursen, Nick S., Dobó, József, Kjaer, Troels R., Sirotkina, Sofia, Yatime, Laure, Sottrup-Jensen, Lars, Thiel, Steffen, Gál, Péter, Andersen, Gregers R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458355/
https://ncbi.nlm.nih.gov/pubmed/22949645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208031109
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