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Substrate recognition by complement convertases revealed in the C5–cobra venom factor complex
Complement acts as a danger-sensing system in the innate immune system, and its activation initiates a strong inflammatory response and cleavage of the proteins C3 and C5 by proteolytic enzymes, the convertases. These contain a non-catalytic substrate contacting subunit (C3b or C4b) in complex with...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034014/ https://ncbi.nlm.nih.gov/pubmed/21217642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.341 |
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