Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

The apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease, likely increasing risk by altering amyloid-β (Aβ) accumulation. We recently demonstrated that the low-density lipoprotein receptor (LDLR) is a major apoE receptor in the brai...

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Main Authors: Castellano, Joseph M., Deane, Rashid, Gottesdiener, Andrew J., Verghese, Philip B., Stewart, Floy R., West, Tim, Paoletti, Andrew C., Kasper, Tristan R., DeMattos, Ronald B., Zlokovic, Berislav V., Holtzman, David M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458349/
https://ncbi.nlm.nih.gov/pubmed/22927427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206446109
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