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Role of genes linked to sporadic Alzheimer’s disease risk in the production of β-amyloid peptides
Alzheimer’s disease (AD) is characterized by the presence of toxic protein aggregates or plaques composed of the amyloid β (Aβ) peptide. Various lengths of Aβ peptide are generated by proteolytic cleavages of the amyloid precursor protein (APP). Mutations in many familial AD-associated genes affect...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3458335/ https://ncbi.nlm.nih.gov/pubmed/22949636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201632109 |
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