Systematic Analysis of Pyrazinamide-Resistant Spontaneous Mutants and Clinical Isolates of Mycobacterium tuberculosis

Pyrazinamide (PZA) is a first-line antitubercular drug known for its activity against persistent Mycobacterium tuberculosis bacilli. We set out to systematically determine the PZA susceptibility profiles and mutations in the pyrazinamidase (pncA) gene of a collection of multidrug-resistant tuberculo...

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Bibliographische Detailangaben
Hauptverfasser: Stoffels, Karolien, Mathys, Vanessa, Fauville-Dufaux, Maryse, Wintjens, René, Bifani, Pablo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457413/
https://ncbi.nlm.nih.gov/pubmed/22825123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05385-11
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