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Cytoplasmic Trafficking, Endosomal Escape, and Perinuclear Accumulation of Adeno-Associated Virus Type 2 Particles Are Facilitated by Microtubule Network

Understanding adeno-associated virus (AAV) trafficking is critical to advance our knowledge of AAV biology and exploit novel aspects of vector development. Similar to the case for most DNA viruses, after receptor binding and entry, AAV traverses the cytoplasm and deposits the viral genome in the cel...

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Autors principals: Xiao, Ping-Jie, Samulski, R. Jude
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457265/
https://ncbi.nlm.nih.gov/pubmed/22811523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00935-12
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