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A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self
The degree of T cell self-reactivity considered dangerous by the immune system, thereby requiring thymic selection processes to prevent autoimmunity, is unknown. Here, we analyzed a panel of T cell receptors (TCRs) with a broad range of reactivity to ovalbumin (OVA(323-339)) in the rat insulin promo...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3456990/ https://ncbi.nlm.nih.gov/pubmed/22921379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.07.009 |
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