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The effects of thymic selection on the range of T cell cross-reactivity

Based on the results of a computational model of thymic selection, we propose a mechanism that produces the observed wide range of T cell cross-reactivity. The model suggests that the cross-reactivity of a T cell that survives thymic selection is correlated with its affinity for self peptides. In or...

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Библиографические подробности
Главные авторы: Chao, Dennis L., Davenport, Miles P., Forrest, Stephanie, Perelson, Alan S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857316/
https://ncbi.nlm.nih.gov/pubmed/16285012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200535098
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