Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.

The adenosine deaminase-resistant purine deoxynucleoside 2-chloro-2'-deoxyadenosine (CdA) is markedly toxic in vitro to nondividing and proliferating normal human lymphocytes and to many leukemia cell specimens. The CdA is also effective against mouse L1210 leukemia in vivo. The present investigatio...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Carson, D A, Wasson, D B, Beutler, E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1984
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6585795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.7.2232
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