Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.

The adenosine deaminase-resistant purine deoxynucleoside 2-chloro-2'-deoxyadenosine (CdA) is markedly toxic in vitro to nondividing and proliferating normal human lymphocytes and to many leukemia cell specimens. The CdA is also effective against mouse L1210 leukemia in vivo. The present investigatio...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Carson, D A, Wasson, D B, Beutler, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1984
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6585795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.7.2232
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