Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-Like Libraries

[Image: see text] The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of representative library members are measur...

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Hlavní autoři: Lowe, Jason T., Lee, Maurice D., Akella, Lakshmi B., Davoine, Emeline, Donckele, Etienne J., Durak, Landon, Duvall, Jeremy R., Gerard, Baudouin, Holson, Edward B., Joliton, Adrien, Kesavan, Sarathy, Lemercier, Berenice C., Liu, Haibo, Marié, Jean-Charles, Mulrooney, Carol A., Muncipinto, Giovanni, Welzel-O’Shea, Morgan, Panko, Laura M., Rowley, Ann, Suh, Byung-Chul, Thomas, Meryl, Wagner, Florence F., Wei, Jingqiang, Foley, Michael A., Marcaurelle, Lisa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454511/
https://ncbi.nlm.nih.gov/pubmed/22853001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo300974j
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