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Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via S(N)Ar Cycloetherification

We have implemented an aldol-based ‘build/couple/pair’ (B/C/P) strategy for the synthesis of stereochemically diverse 8-membered lactam and sultam scaffolds via S(N)Ar cycloetherification. Each scaffold contains two handles, an amine and aryl bromide, for solid-phase diversification via N-capping an...

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Bibliografiske detaljer
Main Authors: Gerard, Baudouin, Duvall, Jeremy R., Lowe, Jason T., Murillo, Tiffanie, Wei, Jingqiang, Akella, Lakshmi B., Marcaurelle, Lisa A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134123/
https://ncbi.nlm.nih.gov/pubmed/21526820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co2000218
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