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Synthesis of a Stereochemically Diverse Library of Medium-Sized Lactams and Sultams via S(N)Ar Cycloetherification
We have implemented an aldol-based ‘build/couple/pair’ (B/C/P) strategy for the synthesis of stereochemically diverse 8-membered lactam and sultam scaffolds via S(N)Ar cycloetherification. Each scaffold contains two handles, an amine and aryl bromide, for solid-phase diversification via N-capping an...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3134123/ https://ncbi.nlm.nih.gov/pubmed/21526820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co2000218 |
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