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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-Like Libraries

[Image: see text] The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of representative library members are measur...

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Detalhes bibliográficos
Main Authors: Lowe, Jason T., Lee, Maurice D., Akella, Lakshmi B., Davoine, Emeline, Donckele, Etienne J., Durak, Landon, Duvall, Jeremy R., Gerard, Baudouin, Holson, Edward B., Joliton, Adrien, Kesavan, Sarathy, Lemercier, Berenice C., Liu, Haibo, Marié, Jean-Charles, Mulrooney, Carol A., Muncipinto, Giovanni, Welzel-O’Shea, Morgan, Panko, Laura M., Rowley, Ann, Suh, Byung-Chul, Thomas, Meryl, Wagner, Florence F., Wei, Jingqiang, Foley, Michael A., Marcaurelle, Lisa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454511/
https://ncbi.nlm.nih.gov/pubmed/22853001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo300974j
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