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Improved drug-like properties of therapeutic proteins by directed evolution
Many natural human proteins have functional properties that make them useful as therapeutic drugs. However, not all these proteins are compatible with large-scale manufacturing processes or sufficiently stable to be stored for long periods prior to use. In this study, we focus on small four-helix bu...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449403/ https://ncbi.nlm.nih.gov/pubmed/22942395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs054 |
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