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Improved drug-like properties of therapeutic proteins by directed evolution

Many natural human proteins have functional properties that make them useful as therapeutic drugs. However, not all these proteins are compatible with large-scale manufacturing processes or sufficiently stable to be stored for long periods prior to use. In this study, we focus on small four-helix bu...

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Detalhes bibliográficos
Main Authors: Buchanan, Andrew, Ferraro, Franco, Rust, Steven, Sridharan, Sudharsan, Franks, Ruth, Dean, Greg, McCourt, Matthew, Jermutus, Lutz, Minter, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449403/
https://ncbi.nlm.nih.gov/pubmed/22942395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs054
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