Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer

SIMPLE SUMMARY: We generated a platform for designing optimized functional therapeutic antibodies against cancer glycans. The target tumor-associated carbohydrate antigen is commonly expressed in colon and pancreatic cancers. We developed a system for selection of potent antibodies by yeast surface...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Amon, Ron, Rosenfeld, Ronit, Perlmutter, Shahar, Grant, Oliver C., Yehuda, Sharon, Borenstein-Katz, Aliza, Alcalay, Ron, Marshanski, Tal, Yu, Hai, Diskin, Ron, Woods, Robert J., Chen, Xi, Padler-Karavani, Vered
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601599/
https://ncbi.nlm.nih.gov/pubmed/33007970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102824
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