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Probing a protein–protein interaction by in vitro evolution
In this study, we used in vitro protein evolution with ribosome and phage display to optimize the affinity of a human IL-13-neutralizing antibody, a therapeutic candidate for the treatment of asthma, >150-fold to 81 pM by using affinity-driven stringency selections. Simultaneously, the antibody p...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458619/ https://ncbi.nlm.nih.gov/pubmed/16684878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602341103 |
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