Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression

Antibodies can undergo a variety of covalent and non-covalent degradation reactions that have adverse effects on efficacy, safety, manufacture and storage. We had identified an antibody to Angiopoietin 2 (Ang2 mAb) that neutralizes Ang2 binding to its receptor in vitro and inhibits tumor growth in v...

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Bibliografske podrobnosti
Main Authors: Buchanan, Andrew, Clementel, Veronica, Woods, Rob, Harn, Nicholas, Bowen, Michael A, Mo, Wenjun, Popovic, Bojana, Bishop, Steven M., Dall’Acqua, William, Minter, Ralph, Jermutus, Lutz, Bedian, Vahe
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893235/
https://ncbi.nlm.nih.gov/pubmed/23412563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23392
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