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Sampling strategies for rare variant tests in case–control studies
Advances in sequencing technology allow assessing the impact of rare variation on common disorders. For this purpose, methods combine rare variants across a gene and compare an aggregate statistic between cases and controls. However, sequencing many individuals is costly. Hence, it is necessary to i...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3449077/ https://ncbi.nlm.nih.gov/pubmed/22510851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2012.58 |
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