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Association Testing of Clustered Rare Causal Variants in Case-Control Studies
Biological evidence suggests that multiple causal variants in a gene may cluster physically. Variants within the same protein functional domain or gene regulatory element would locate in close proximity on the DNA sequence. However, spatial information of variants is usually not used in current rare...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988195/ https://ncbi.nlm.nih.gov/pubmed/24736372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094337 |
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