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Rare Variant Association Testing by Adaptive Combination of P-values
With the development of next-generation sequencing technology, there is a great demand for powerful statistical methods to detect rare variants (minor allele frequencies (MAFs)<1%) associated with diseases. Testing for each variant site individually is known to be underpowered, and therefore many...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893264/ https://ncbi.nlm.nih.gov/pubmed/24454922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085728 |
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