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Quantitative DMS mapping for automated RNA secondary structure inference

For decades, dimethyl sulfate (DMS) mapping has informed manual modeling of RNA structure in vitro and in vivo. Here, we incorporate DMS data into automated secondary structure inference using an energy minimization framework developed for 2′-OH acylation (SHAPE) map-ping. On six non-coding RNAs wit...

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Bibliographic Details
Main Authors: Cordero, Pablo, Kladwang, Wipapat, VanLang, Christopher C., Das, Rhiju
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448840/
https://ncbi.nlm.nih.gov/pubmed/22913637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3008802
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