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A two-dimensional mutate-and-map strategy for non-coding RNA structure
Non-coding RNAs fold into precise base-pairing patterns to carry out critical roles in genetic regulation and protein synthesis, but determining RNA structure remains difficult. Here, we show that coupling systematic mutagenesis with high-throughput chemical mapping enables accurate base-pair infere...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725140/ https://ncbi.nlm.nih.gov/pubmed/22109276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1176 |
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