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Single-molecule FRET reveals an innate fidelity checkpoint in DNA polymerase I

Enzymatic reactions typically involve complex dynamics during substrate binding, conformational rearrangement, chemistry and product release. The non-covalent steps provide kinetic checkpoints that contribute to the overall specificity of enzymatic reactions. DNA polymerases perform DNA replication...

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Detalhes bibliográficos
Main Authors: Berezhna, Svitlana Y., Gill, Joshua P., Lamichhane, Rajan, Millar, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448555/
https://ncbi.nlm.nih.gov/pubmed/22650319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3038273
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