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Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin
Cardiac α-tropomyosin (Tm) single site mutations, D175N and E180G, cause familial hypertrophic cardiomyopathy (FHC). Previous studies have shown that these mutations increase both Ca(2+)-sensitivity and residual contractile activity at low Ca(2+), which causes incomplete relaxation during diastole r...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447992/ https://ncbi.nlm.nih.gov/pubmed/22794249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3006835 |
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