Llwytho...

Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin

Cardiac α-tropomyosin (Tm) single site mutations, D175N and E180G, cause familial hypertrophic cardiomyopathy (FHC). Previous studies have shown that these mutations increase both Ca(2+)-sensitivity and residual contractile activity at low Ca(2+), which causes incomplete relaxation during diastole r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ly, Socheata, Lehrer, Sherwin S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447992/
https://ncbi.nlm.nih.gov/pubmed/22794249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3006835
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