Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin

α-tropomyosin (αTm) is central to Ca(2+)-regulation of cardiac muscle contraction. The familial hypertrophic cardiomyopathy mutation αTm E180G enhances Ca(2+)-sensitivity in functional assays. To investigate the molecular basis, we imaged single molecules of human cardiac αTm E180G by direct probe a...

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Hlavní autoři: Loong, Campion K. P., Zhou, Huan-Xiang, Chase, P. Bryant
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3455129/
https://ncbi.nlm.nih.gov/pubmed/22958892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.08.005
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