The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy

Point mutations targeting muscle thin filament proteins are the cause of a number of cardiomyopathies. In many cases, biological effects of the mutations are well-documented, whereas their structural and mechanical impact on filament assembly and regulatory function is lacking. In order to elucidate...

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Bibliographic Details
Main Authors: Li, Xiaochuan (Edward), Suphamungmee, Worawit, Janco, Miro, Geeves, Michael A., Marston, Steven B., Fischer, Stefan, Lehman, William
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412897/
https://ncbi.nlm.nih.gov/pubmed/22789852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.06.141
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