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Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin
α-tropomyosin (αTm) is central to Ca(2+)-regulation of cardiac muscle contraction. The familial hypertrophic cardiomyopathy mutation αTm E180G enhances Ca(2+)-sensitivity in functional assays. To investigate the molecular basis, we imaged single molecules of human cardiac αTm E180G by direct probe a...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3455129/ https://ncbi.nlm.nih.gov/pubmed/22958892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.08.005 |
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