Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer

BACKGROUND: 3-Aminopyridine-2-carboxaldehydethiosemicarbazone (3-AP) is a novel small molecule ribonucleotide reductase (RR) inhibitor which is more potent than hydroxyurea, the prototype of RR inhibitors. 3-AP enhances the cellular uptake and DNA incorporation of gemcitabine in tumor cell lines. We...

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Détails bibliographiques
Auteurs principaux: Ocean, Allyson J., Christos, Paul, Sparano, Joseph A., Matulich, Dan, Kaubish, Andreas, Siegel, Abby, Sung, Max, Ward, Maureen M., Hamel, Nancy, Espinoza-Delgado, Igor, Yen, Yun, Lane, Maureen E.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446256/
https://ncbi.nlm.nih.gov/pubmed/20981545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1481-z
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