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Pancreatic β-Cell Dedifferentiation As Mechanism Of Diabetic β-Cell Failure

Diabetes is associated with β-cell failure. But it remains unclear whether the latter results from reduced β-cell number or function. FoxO1 integrates β-cell proliferation with adaptive β-cell function. We interrogated the contribution of these two processes to β-cell dysfunction, using mice lacking...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Talchai, Chutima, Xuan, Shouhong, Lin, Hua V., Sussel, Lori, Accili, Domenico
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445031/
https://ncbi.nlm.nih.gov/pubmed/22980982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.029
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