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Generation Of Functional Insulin-Producing Cells In The Gut By Foxo1 Ablation
Restoration of regulated insulin secretion is the ultimate goal of type 1 diabetes therapy. Here we show that, surprisingly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive cells (Ins(+)) that express markers of mature β-cells, and secrete...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315609/ https://ncbi.nlm.nih.gov/pubmed/22406641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2215 |
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