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Generation Of Functional Insulin-Producing Cells In The Gut By Foxo1 Ablation

Restoration of regulated insulin secretion is the ultimate goal of type 1 diabetes therapy. Here we show that, surprisingly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive cells (Ins(+)) that express markers of mature β-cells, and secrete...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Talchai, Chutima, Xuan, Shouhong, Kitamura, Tadahiro, DePinho, Ronald A., Accili, Domenico
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315609/
https://ncbi.nlm.nih.gov/pubmed/22406641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2215
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