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Generation Of Functional Insulin-Producing Cells In The Gut By Foxo1 Ablation
Restoration of regulated insulin secretion is the ultimate goal of type 1 diabetes therapy. Here we show that, surprisingly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive cells (Ins(+)) that express markers of mature β-cells, and secrete...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2012
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315609/ https://ncbi.nlm.nih.gov/pubmed/22406641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2215 |
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