Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

CONTEXT: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage, and partly converting to other endocrine cell types. OBJECTIVE: To determine whether similar processes occur in hum...

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Detalles Bibliográficos
Publicado en:J Clin Endocrinol Metab
Autores principales: Cinti, Francesca, Bouchi, Ryotaro, Kim-Muller, Ja Young, Ohmura, Yoshiaki, Sandoval, P. R., Masini, Matilde, Marselli, Lorella, Suleiman, Mara, Ratner, Lloyd E., Marchetti, Piero, Accili, Domenico
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803182/
https://ncbi.nlm.nih.gov/pubmed/26713822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-2860
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