Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α(5)β(1) and ERK-Dependent Signaling Pathways

Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α(5)β(1) integrin, identify the downstream signal transduction pathway, and further investigate...

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Detalhes bibliográficos
Main Authors: Clarke, Douglas N., Al Ahmad, Abraham, Lee, Boyeon, Parham, Christi, Auckland, Lisa, Fertala, Andrezj, Kahle, Michael, Shaw, Courtney S., Roberts, Jill, Bix, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444475/
https://ncbi.nlm.nih.gov/pubmed/23028886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045257
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