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Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α(5)β(1) and ERK-Dependent Signaling Pathways
Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α(5)β(1) integrin, identify the downstream signal transduction pathway, and further investigate...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444475/ https://ncbi.nlm.nih.gov/pubmed/23028886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045257 |
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