Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α(5)β(1) and ERK-Dependent Signaling Pathways

Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α(5)β(1) integrin, identify the downstream signal transduction pathway, and further investigate...

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Main Authors: Clarke, Douglas N., Al Ahmad, Abraham, Lee, Boyeon, Parham, Christi, Auckland, Lisa, Fertala, Andrezj, Kahle, Michael, Shaw, Courtney S., Roberts, Jill, Bix, Gregory J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444475/
https://ncbi.nlm.nih.gov/pubmed/23028886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045257
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