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Perlecan Domain V Inhibits Amyloid-β Induced Brain Endothelial Cell Toxicity and Restores Angiogenic Function

In Alzheimer’s disease (AD), amyloid-β (Aβ) deposits in the cerebrovasculature can result in neurovascular dysfunction and/or cerebral amyloid angiopathy. The accumulation of Aβ in blood vessels can cause endothelial cell damage, resulting in impaired Aβ clearance by the blood-brain barrier. Additio...

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Hlavní autoři: Parham, Christi, Auckland, Lisa, Rachwal, Jessica, Clarke, Douglas, Bix, Gregory
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3996518/
https://ncbi.nlm.nih.gov/pubmed/23979025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-130683
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