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High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
BACKGROUND: Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect against APAP-induced acute liver injury (ALI) at 9 h time point, the later tim...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
BioMed Central
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444430/ https://ncbi.nlm.nih.gov/pubmed/22569100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-12-45 |
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