Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice

BACKGROUND & AIMS: Acetaminophen (APAP)-induced liver injury is one of the most common causes of acute liver failure, however, a clear definition of sensitizing risk factors is lacking. Here, we investigated the role of the ligand-activated transcription factor aryl hydrocarbon receptor (Ahr) in...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Schuran, Fenja A., Lommetz, Christoph, Steudter, Andreas, Ghallab, Ahmed, Wieschendorf, Björn, Schwinge, Dorothee, Zuehlke, Sebastian, Reinders, Joerg, Heeren, Joerg, Lohse, Ansgar W., Schramm, Christoph, Herkel, Johannes, Carambia, Antonella
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779786/
https://ncbi.nlm.nih.gov/pubmed/32932016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.09.002
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